Handbook of HER2-targeted agents in breast cancer

by Michael Gandy (Contributor), Luca Gianni (Contributor), Luca Gianni (Contributor), Leticia Mattos-Arruda (Contributor), Javier Cortés (Contributor), Michael Gandy (Contributor), Angelica Fasolo (Contributor), Mary Falzon (Contributor), Martine Piccart (Contributor), Stefania Zambelli (Contributor), Ricardo H H. Alvarez (Author), Nadia Harbeck (Contributor)

• New

  Paperback
  2014

  $42.86

  Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15-25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.