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Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues

by Daniel Best (Author), Mickael Jean (Contributor), Pierre Van De Weghe (Contributor)

  • New

    Hardcover 2016

    $116.55
Synopsis

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

$116.55

Quantity

20+ in stock

More Information

Format: Hardcover
 Pages: 144
 Publisher: ISTEPELS
Published: 14 Jun 2016
ISBN 10: 1785481509
ISBN 13: 9781785481505
Book Overview: This detailed resource describes the isolation of dynemicin and uncialamycin, provides a brief overview of their biological activities (and potential development as drugs), and presents the various synthetic routes to prepare these compounds and their analogues. Covers a complete field of organic chemistry at the interface with biological science.

Author Bio
Daniel Best is a postdoctoral researcher at the University of Rennes 1 in France. He is currently developing the synthesis of uncialamycin analogues. Mickael Jean is Associate Professor at the University of Rennes 1 in France. His research is concerned with the challenges of total synthesis of natural products and the development of anti-cancer medical chemistry programs. Pierre van de Weghe is Professor in organic chemistry at the University of Rennes 1 in France. His work focuses on the total synthesis of natural products and analogues, as well as research into new components in anti-cancer activity..