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PBPK Science and Apps: Science and Applications

PBPK Science and Apps: Science and Applications

by Andersen (Author), Reddy (Author), Clewell I I I (Author)

  • New

    Illustrated 2005

    $189.02
Synopsis

This book offers a definitive, single source of information on PBPK modeling. Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind. This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for: Halogenated Alkanes; Halogenated Alkenes; Alkene and Aromatic Compounds; Reactive Vapors in the Nasal Cavity; Alkanes, Oxyhydrocarbons, and Related Compounds; Pesticides and Persistent Organic Pollutants; Dioxin and Related Compounds; Metals and Inorganic Compounds; Drugs; Antineoplastic Agents; Perinatal Transfer; Mixtures; and Dermal Exposure Models. In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.

$189.02

Quantity

20+ in stock

More Information

Format: Illustrated
 Pages: 442
 Edition: 1
 Publisher: John Wiley & Sons
Published: 09 Jun 2005
ISBN 10: 0471478148
ISBN 13: 9780471478140

Media Reviews
This is a comprehensive, useful book, a valuable reference for toxicologists, regulators, pharmacologists, pharmacists, and graduate students... (American Journal of Therapeutics, March/April 2006)
Author Bio
The EDITORS have worked together on PBPK research and in teaching PBPK modeling workshops and courses through the Quantitative and Computation Toxicology research group at the Center for Environ-mental Toxicology and Technology (CETT) in the Department of Environmental and Radiological Health Sciences at Colorado State University (CSU). MICAELA B. REDDY, PhD, is a research professor at CETT where she has developed PBPK models for risk assessment and toxicology applications. RAYMOND S. H. YANG, PhD, Professor of Toxicology and former director, CETT, championed applications of PBPK modeling in research on the toxicology of chemical mixtures. HARVEY J. CLEWELL III, MS, Director, Center for Human Health Assessment, CIIT Centers for Health Research, Research Triangle Park, North Carolina, played a major role in the first uses of PBPK modeling in cancer and non-cancer risk assessments by several federal agencies, including EPA, ATSDR, OSHA, and FDA. MELVIN E. ANDERSEN, PhD, a pioneer in use of PBPK modeling in toxicology and risk assessment, is Director, Computational Biology Division, CIIT Centers for Health Research, Research Triangle Park, North Carolina.