An Introduction to Medicinal Chemistry, 2nd Ed.

by Graham L . Patrick (Author)

• Used

  Paperback
  2001

  $4.18

  This lively, highly illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies involved in developing an effective drug. Through the use of numerous examples it highlights both the difficulties faced by the medicinal chemist and the great potential of rational drug design. The second edition has five new chapters and is updated to include recent advances in the field. It is updated throughout with the latest descoveries. There are five new chapters covering: the molecular structure of receptors and the mechanisms of signal transduction; combinatorial synthesis; the role of computers in drug design; adrenergics; and drug discovery and drug development.

• Used

  Paperback
  2005

  $4.99

  Many of us think nothing of taking a painkiller to ease a headache, or to relieve the symptoms of 'flu. But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaging insight into the one field of chemistry that arguably has the greatest impact on our quality of life than any other. Newly structured into four parts, the book opens in Part A with an introduction to pharmacodynamics and pharmacokinetics. Pharmacodynamics considers the types of molecular targets used by drugs, the interactions which are involved when a drug meets that target, and the consequences of those interactions. Pharmacokinetics considers the issues involved in a drug reaching its target in the first place. Part B goes on to examine the general principles and strategies involved in discovering and designing new drugs and developing them for the marketplace, while Part C looks at particular 'tools of the trade' which are invaluable in those processes. Finally, Part D covers a selection of specific topics within medicinal chemistry. Reflecting a change in emphasis in medicinal chemistry research, this Part takes us from the largely trial-and-error approach to drug design to the rational approach, and explores the most recent advances in molecular biology and genetics which have revolutionised drug design. With a striking new two-colour text design, and greatly enriched learning features, the third edition conveys the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, physiology, microbiology, cell biology, and pharmacology. A must-have textbook for any student of medicinal chemistry. Companion Web Site features figures available to download, to facilitate lecture preparation, 3D molecular structures, to enable students to visualise key structures in an interactive way and multiple choice questions with answers, to support and encourage independent learning.