Free Radicals in Biology and Medicine (Oxford Science Publications)

by Barry Halliwell (Author), JohnM.C.Gutteridge (Author)

• Used

  Paperback
  1999

  $3.42

  Since the publication of the second edition of Free Radicals in Biology and Medicine in 1989 the techniques of modern molecular, cellular, and structural biology have provided new data that have transformed scientific thinking about topics within free radical research. New reactive species, such as peroxynitrite, have been discovered to have a role in biological systems. Therefore much of the third edition has been completely rewritten and what remains from the second has been thoroughly updated. There are new chapters on antioxidant defence systems in bacteria, plants, and animals; the detection of free radicals; the role of antioxidants in ageing, nutrition, disease, and therapy; and a new appendix on molecular biology. The chapter on oxidative stress and its consequences includes the damage and repair of DNA, proteins, and lipids, cytokines, and cell death (both apoptosis and necrosis). Free radicals and other reactive species are now implicated in a wide range and number of diseases and the third edition covers their role in hypertension, diabetes, lung damage, cystic fibrosis, nervous system disorders, viral infections, and cancer. The toxicology chapter has been updated to include new sections on complex mixtures, nitro- and azo- compounds, and radiation. Erythrocytes, chloroplasts, the eye, the skin, reproduction, and exercise are covered as special cases of oxidative stress and antioxidant protection. Reactive species can act as useful biomolecules and this role is fully discussed. There is also an up-to-date introduction to free radical chemistry (as well as a basic chemistry appendix) and oxygen toxicity. Each major statement in the text is referenced. The authors have maintained the simplicity of approach and readability of the previous editions to make this book an invaluable companion to all those interested in the role of free radicals in life.

• Used

  Paperback
  1989

  $6.10

  The importance of radical reactions in radiation damage, food preservation, combustion and in the rubber and paint industry has been known for many years. The interest shown in this field by biologists and clinicians has been raised recently by the discovery of the importance of radical reactions in normal body chemistry and in the mode of action of many toxins. The discoveries of hypoxic cell sensitizers that potentiate radiation-induced radical damage to cancerous tumours, of the enzyme superoxide dismutase, and of the mechanism of action of such toxins as paraquet and carbon tetrachloride provide major examples of this importance. Designed for biologists and clinicians who have little knowledge of chemistry, this text provides an understanding of the nature of free radicals. It explains what they are, how they are generated and how they react. Having established this basis, the role of radical reactions in several biological systems is evaluated in the hope that the careful techniques needed to prove their importance will become more widely used. This edition of the text has been extensively rewritten and the authors have updated references to include recent research in this area.