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The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

by RichardB.SilvermanPh.DOrganicChemistry (Author)

  • Used

    Hardcover 2004

    $7.15
Synopsis

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.

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More Information

Format: Hardcover
 Pages: 617
 Edition: 2
 Publisher: Academic Press
Published: 19 Feb 2004
ISBN 10: 0126437327
ISBN 13: 9780126437324
Book Overview: * Organic chemist's perspective of how drugs are designed and function * Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples * Extensive use of references to the primary and secondary literature for more in depth reading about all concepts * Extensive use of structures, schemes, and figures to illustrate points * Explanations of dual-acting drugs * Problem sets and answers for each topic * Casual writing style * Author has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.

Media Reviews
Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development. -Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004 What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs. -ORGANIC CHEMISTRY ORG., 2005 Praise for the New Edition: ...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry. --JOURNAL OF MEDICINAL CHEMISTRY Praise for the First Edition: This book is a tour de force...appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration. --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ... unified, well-organized and clearly presented...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data ... --Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way... --William C. Groutas, Wichita State University ...The organization of this book and the clarity of presentation are outstanding...It is highly recommended... --JOURNAL OF MEDICINAL CHEMISTRY
Author Bio
Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Professor Robert Abeles in the Graduate Department of Biochemistry at Brandeis University, he joined the chemistry faculty at Northwestern University. In 1986, he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001, he became the Charles Deering McCormick Professor of Teaching Excellence for three years, and since 2004 he has been the John Evans Professor of Chemistry. His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents acting on enzymes and receptors. His awards include DuPont Young Faculty Fellow (1976), Alfred P. Sloan Research Fellow (1981-1985), NIH Research Career Development Award (1982-1987), Fellow of the American Institute of Chemists (1985), Fellow of the American Association for the Advancement of Science (1990), Arthur C. Cope Senior Scholar Award of the American Chemical Society (2003), Alumni Fellow Award from Pennsylvania State University (2008), Medicinal Chemistry Hall of Fame of the American Chemical Society (2009), the Perkin Medal from the Society of Chemical Industry (2009), the Hall of Fame of Central High School of Philadelphia (2011), the E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society (2011), Fellow of the American Chemical Society (2011), Sato Memorial International Award of the Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of Wayne State University (2013), BMS-Edward E. Smissman Award of the American Chemical Society (2013), the Centenary Prize of the Royal Society of Chemistry (2013), and the Excellence in Medicinal Chemistry Prize of the Israel Chemical Society (2014). Professor Silverman has published over 320 research and review articles, holds 49 domestic and foreign patents, and has written four books (The Organic Chemistry of Drug Design and Drug Action is translated into German and Chinese). He is the inventor of LyricaTM, a drug marketed by Pfizer for epilepsy, neuropathic pain, fibromyalgia, and spinal cord injury pain; currently, he has another CNS drug in clinical trials.